N-[4-[2-tert-butyl-4-(2,4-dioxopyrimidin-1-yl)quinazolin-7-yl]phenyl]methanesulfonamide

Base Information

Chemical Name:N-[4-[2-tert-butyl-4-(2,4-dioxopyrimidin-1-yl)quinazolin-7-yl]phenyl]methanesulfonamide
CAS No.:1354455-81-4
Molecular Formula:C₂₃H₂₃N₅O₄S
Molecular Weight:465.533
Hs Code.:

Synonyms:N-[4-[2-tert-butyl-4-(2,4-dioxopyrimidin-1-yl)quinazolin-7-yl]phenyl]methanesulfonamide

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Chemical Property of N-[4-[2-tert-butyl-4-(2,4-dioxopyrimidin-1-yl)quinazolin-7-yl]phenyl]methanesulfonamide

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Technology Process of N-[4-[2-tert-butyl-4-(2,4-dioxopyrimidin-1-yl)quinazolin-7-yl]phenyl]methanesulfonamide

There total 6 articles about N-[4-[2-tert-butyl-4-(2,4-dioxopyrimidin-1-yl)quinazolin-7-yl]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1354455-88-1
N-[4-(2-tert-butyl-4-chloroquinazolin-7-yl)phenyl]methanesulfonamide

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 1354455-81-4
N-[4-[2-tert-butyl-4-(2,4-dioxopyrimidin-1-yl)quinazolin-7-yl]phenyl]methanesulfonamide

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 125 ℃; for 2.5h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm401329s

Reference yield:

: 1354455-87-0
C₁₉H₂₁N₃O₃S

: 1354455-81-4
N-[4-[2-tert-butyl-4-(2,4-dioxopyrimidin-1-yl)quinazolin-7-yl]phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / benzene / 6.5 h / Inert atmosphere; Reflux

2: caesium carbonate / dimethyl sulfoxide / 2.5 h / 125 °C / Inert atmosphere; Sealed tube

With caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dimethyl sulfoxide; benzene;
DOI:10.1021/jm401329s

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1354455-81-4
N-[4-[2-tert-butyl-4-(2,4-dioxopyrimidin-1-yl)quinazolin-7-yl]phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

1.2: 1.5 h / Inert atmosphere; Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; toluene / 0.5 h / 115 °C / Inert atmosphere; Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / benzene / 6.5 h / Inert atmosphere; Reflux

4.1: caesium carbonate / dimethyl sulfoxide / 2.5 h / 125 °C / Inert atmosphere; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; dichloromethane; dimethyl sulfoxide; toluene; benzene;
DOI:10.1021/jm401329s