tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

Base Information

Chemical Name:tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate
CAS No.:1361407-77-3
Molecular Formula:C₂₅H₃₅NO₇
Molecular Weight:461.555
Hs Code.:

Synonyms:tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

Suppliers and Price of tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

There total 5 articles about tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41108-81-0
tert-butyl (trimethylsilyl)acetate

: 1361407-62-6
(4R,5S)-5-acetyl-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-one

: 1361407-77-3
tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

: 1361407-66-0
tert-butyl (E)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

Guidance literature:: tert-butyl (trimethylsilyl)acetate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 2.5h; Inert atmosphere;

(4R,5S)-5-acetyl-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-one; In tetrahydrofuran; hexane; at -78 ℃; for 4h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jm2016914

Reference yield:

: 1275576-22-1
(R)-N-(tert-butoxycarbonyl)-2-amino-3-(p-methyloxyphenyl)-N-methoxy-N-methylpropionamide

: 1361407-77-3
tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2.1: cerium(III) chloride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C / Inert atmosphere; Reflux

3.2: 2 h / 0 °C / Inert atmosphere

4.1: dimethylsulfide; ozone / ethyl acetate / 0.25 h / -78 - 0 °C

5.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.5 h / -78 - 0 °C / Inert atmosphere

5.2: 4 h / -78 °C / Inert atmosphere

With n-butyllithium; cerium(III) chloride; dimethylsulfide; sodium hydride; ozone; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate; mineral oil; 5.1: Peterson olefination / 5.2: Peterson olefination;
DOI:10.1021/jm2016914

Reference yield:

: 1361407-61-5
(3R,4R)-4-[N-(tert-butoxycarbonyl)amino]-5-(4-methoxyphenyl)-2,3-dimethylpent-1-en-3-ol

: 1361407-77-3
tert-butyl (Z)-3-[(4R,5R)-N-(tert-butoxycarbonyl)-4-(4-methoxybenzyl)-5-methyl-1,3-oxazolidin-2-on-5-yl]but-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C / Inert atmosphere; Reflux

1.2: 2 h / 0 °C / Inert atmosphere

2.1: dimethylsulfide; ozone / ethyl acetate / 0.25 h / -78 - 0 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.5 h / -78 - 0 °C / Inert atmosphere

3.2: 4 h / -78 °C / Inert atmosphere

With n-butyllithium; dimethylsulfide; sodium hydride; ozone; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate; mineral oil; 3.1: Peterson olefination / 3.2: Peterson olefination;
DOI:10.1021/jm2016914