5-(3-Bromo-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester

Base Information

• Chemical Name: 5-(3-Bromo-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester
• CAS No.: 182758-05-0
• Molecular Formula: C₁₅H₁₃BrI₃NO₅
• Molecular Weight: 747.889

Synonyms:5-(3-Bromo-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester

Chemical Property of 5-(3-Bromo-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester

Chemical Property:

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Technology Process of 5-(3-Bromo-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester

There total 3 articles about 5-(3-Bromo-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-(2,5-Dibromo-pentanoylamino)-2,4,6-triiodo-isophthalic acid dimethyl ester (182758-13-0) → 5-(3-Bromo-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester (182758-05-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; for 0.5h; Ambient temperature;

DOI:10.1016/0040-4020(96)00668-0

Reference yield:

2,5-Dibromopentanoic Acid Bromide (89180-84-7) → 5-(3-Bromo-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester (182758-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / N,N-dimethyl-acetamide / 20 h / Ambient temperature

2: 73 percent / K₂CO₃ / N,N-dimethyl-acetamide / 0.5 h / Ambient temperature

With potassium carbonate; In N,N-dimethyl acetamide;

DOI:10.1016/0040-4020(96)00668-0

Reference yield:

dimethyl 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylate (154921-11-6) → 5-(3-Bromo-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester (182758-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / N,N-dimethyl-acetamide / 20 h / Ambient temperature

2: 73 percent / K₂CO₃ / N,N-dimethyl-acetamide / 0.5 h / Ambient temperature

With potassium carbonate; In N,N-dimethyl acetamide;

DOI:10.1016/0040-4020(96)00668-0

upstream raw materials:

5-(2,5-Dibromo-pentanoylamino)-2,4,6-triiodo-isophthalic acid dimethyl ester

2,5-Dibromopentanoic Acid Bromide

dimethyl 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylate

Downstream raw materials:

5-(3-Acetoxy-2-oxo-piperidin-1-yl)-2,4,6-triiodo-isophthalic acid dimethyl ester

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