8-chloro-3-(chloromethyl)-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline hydrochloride

Base Information

Chemical Name:8-chloro-3-(chloromethyl)-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline hydrochloride
CAS No.:1065481-68-6
Molecular Formula:C₁₇H₉Cl₂F₄N*ClH
Molecular Weight:410.626
Hs Code.:

Synonyms:8-chloro-3-(chloromethyl)-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline hydrochloride

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Chemical Property of 8-chloro-3-(chloromethyl)-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline hydrochloride

Chemical Property:

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Technology Process of 8-chloro-3-(chloromethyl)-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline hydrochloride

There total 4 articles about 8-chloro-3-(chloromethyl)-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1065481-67-5
(8-chloro-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinolin-3-yl)methanol

: 1065481-68-6
8-chloro-3-(chloromethyl)-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline hydrochloride

Guidance literature:: With thionyl chloride; In chloroform; at 20 ℃; for 3h;

Reference yield:

: 4470-83-1
2,8-dichloroquinoline

: 1065481-68-6
8-chloro-3-(chloromethyl)-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexene / 2 h / -78 °C

1.2: 4 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 14 h / 100 °C

3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

4.1: thionyl chloride / chloroform / 3 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; chloroform; water; acetonitrile; cyclohexene;

Reference yield:

: 144918-96-7
2,8-dichloroquinoline-3-carbaldehyde

: 1065481-68-6
8-chloro-3-(chloromethyl)-2-(5-fluoro-2-(trifluoromethyl)phenyl)quinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 14 h / 100 °C

2: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

3: thionyl chloride / chloroform / 3 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; chloroform; water; acetonitrile;