Technology Process of (2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester
There total 17 articles about (2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid (S)-1-benzyloxycarbonyl-2-methyl-propyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 97 percent / imidazole / dimethylformamide / 10 h / 20 °C
2.1: 98 percent / NaH / dimethylformamide / 12 h / 20 °C
3.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C
3.2: NaOOH / 3 h / 50 °C
3.3: TEMPO; NaOCl; NaClO2 / acetonitrile; aq. phosphate buffer / 4.5 h / 20 °C / pH 6.8
4.1: 89 percent / EDCI; DMAP / CH2Cl2 / 8 h / 40 °C
5.1: H2 / Pd(OH)2 / ethanol / 1 h / 20 °C / 760 Torr
6.1: 97 percent / EDCI; DMAP / CH2Cl2 / 12 h / 20 °C
With
1H-imidazole; dmap; 9-borabicyclo[3.3.1]nonane dimer; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 97 percent / imidazole / dimethylformamide / 10 h / 20 °C
2.1: 98 percent / NaH / dimethylformamide / 12 h / 20 °C
3.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C
3.2: NaOOH / 3 h / 50 °C
3.3: TEMPO; NaOCl; NaClO2 / acetonitrile; aq. phosphate buffer / 4.5 h / 20 °C / pH 6.8
4.1: 89 percent / EDCI; DMAP / CH2Cl2 / 8 h / 40 °C
5.1: H2 / Pd(OH)2 / ethanol / 1 h / 20 °C / 760 Torr
6.1: 97 percent / EDCI; DMAP / CH2Cl2 / 12 h / 20 °C
With
1H-imidazole; dmap; 9-borabicyclo[3.3.1]nonane dimer; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 42 percent / Candida antarctica (fraction B) / toluene / 60 h / 20 °C
2: 85 percent / K2CO3 / methanol / 1 h / 20 °C
3: 71 percent / chiral ruthenium complex / CH2Cl2 / 12 h / 20 °C
4: 82 percent / H2 / Pd/C / ethanol / 2 h / 760 Torr
5: aq. NaOH / methanol / 5 h / 20 °C
6: Cs2CO3 / dimethylformamide / 12 h / 20 °C
7: 89 percent / EDCI; DMAP / CH2Cl2 / 8 h / 40 °C
8: H2 / Pd(OH)2 / ethanol / 1 h / 20 °C / 760 Torr
9: 97 percent / EDCI; DMAP / CH2Cl2 / 12 h / 20 °C
With
dmap; sodium hydroxide; Candida antarctica (fraction B); hydrogen; potassium carbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium dihydroxide; palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
