2-Diazo-3-(4-methoxy-phenyl)-3-trimethylsilanyloxy-propionic acid ethyl ester

Base Information

Chemical Name:2-Diazo-3-(4-methoxy-phenyl)-3-trimethylsilanyloxy-propionic acid ethyl ester
CAS No.:59840-32-3
Molecular Formula:C₁₅H₂₂N₂O₄Si
Molecular Weight:322.436
Hs Code.:

Synonyms:2-Diazo-3-(4-methoxy-phenyl)-3-trimethylsilanyloxy-propionic acid ethyl ester

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Chemical Property of 2-Diazo-3-(4-methoxy-phenyl)-3-trimethylsilanyloxy-propionic acid ethyl ester

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Technology Process of 2-Diazo-3-(4-methoxy-phenyl)-3-trimethylsilanyloxy-propionic acid ethyl ester

There total 1 articles about 2-Diazo-3-(4-methoxy-phenyl)-3-trimethylsilanyloxy-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17145-48-1
ethyl 2-diazo-2-(trimethylsilyl)acetate

: 123-11-5
4-methoxy-benzaldehyde

: 59840-32-3
2-Diazo-3-(4-methoxy-phenyl)-3-trimethylsilanyloxy-propionic acid ethyl ester

Guidance literature:: With potassium cyanide; 18-crown-6 ether;
DOI:10.1021/jo00882a034

Reference yield: 50.0%

: 59840-32-3
2-Diazo-3-(4-methoxy-phenyl)-3-trimethylsilanyloxy-propionic acid ethyl ester

: 123-11-5
4-methoxy-benzaldehyde

: 3-hydroxy-2-(4-methoxyphenyl)acrylic acid ethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1016/S0040-4039(99)00932-6

Reference yield:

: 59840-32-3
2-Diazo-3-(4-methoxy-phenyl)-3-trimethylsilanyloxy-propionic acid ethyl ester

: 3-hydroxy-2-(4-methoxyphenyl)acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / CH₂Cl₂

2: 72 percent / ZnCl₂; chlorotrimethylsilane / CH₂Cl₂ / 0.5 h / 0 °C

With chloro-trimethyl-silane; toluene-4-sulfonic acid; zinc(II) chloride; In dichloromethane; 1: Rearrangement / 2: Rearrangement;
DOI:10.1016/S0040-4039(99)00932-6