N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester

Base Information

Chemical Name:N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester
CAS No.:89028-34-2
Molecular Formula:C₅₄H₆₃N₅O₈S₂
Molecular Weight:974.255
Hs Code.:

Synonyms:N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester

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Chemical Property of N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester

There total 7 articles about N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21947-98-8,87494-13-1
N-tert-butyloxycarbonyl-S-trityl-L-cysteine

: 89028-34-2
N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) N-methylmorpholin, HCl; 2) N-hydroxysuccinimid, DCCI / 1) methanol, 2 h; 2) 2 h, -5 deg C; 3 h, 0 deg C

2: 67 percent / hydrazine / methanol / 0.33 h / Heating

3: 1) tert-butylnitrit, HCl, N-methylmorpholine; 2) / 1) THF, methanol, 1 h, -30 deg C; 2) 1 h, -15 deg C, methanol, 3 h, -5 deg C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; tert.-butylnitrite; dicyclohexyl-carbodiimide; hydrazine; In methanol;

Reference yield:

: 21947-97-7
N-(t-butyloxycarbonyl)-S-(diphenylmethyl)-L-cysteine

: 89028-34-2
N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / triethylamine, N-hydroxysuccinimide, DCCI / tetrahydrofuran; methanol / 1) 2 h, -5 deg C; 2) 2 h, 0 deg C

2: 1) N-methylmorpholin, HCl; 2) N-hydroxysuccinimid, DCCI / 1) methanol, 2 h; 2) 2 h, -5 deg C; 3 h, 0 deg C

3: 67 percent / hydrazine / methanol / 0.33 h / Heating

4: 1) tert-butylnitrit, HCl, N-methylmorpholine; 2) / 1) THF, methanol, 1 h, -30 deg C; 2) 1 h, -15 deg C, methanol, 3 h, -5 deg C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; tert.-butylnitrite; triethylamine; dicyclohexyl-carbodiimide; hydrazine; In tetrahydrofuran; methanol;

Reference yield:

: 79638-93-0
(-)-glycinyl-(S)-valine methyl ester hydrochloride

: 89028-34-2
N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / methanol / 0.5 h / Ambient temperature

2: 1) tert-butylnitrit, HCl, N-methylmorpholine; 2) / 1) THF, methanol, 1 h, -30 deg C; 2) 1 h, -15 deg C, methanol, 3 h, -5 deg C

With 4-methyl-morpholine; hydrogenchloride; tert.-butylnitrite; In methanol;