N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-hydrazid

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Chemical Name:N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-hydrazid
CAS No.:89028-35-3
Molecular Formula:C₅₃H₆₃N₇O₇S₂
Molecular Weight:974.258
Hs Code.:

Synonyms:N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-hydrazid

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Chemical Property of N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-hydrazid

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Technology Process of N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-hydrazid

There total 9 articles about N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-hydrazid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 89028-34-2
N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-methylester

: 89028-35-3
N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-hydrazid

Guidance literature:: With hydrazine hydrate; In methanol; at 60 ℃; for 0.333333h;

Reference yield:

: 21947-98-8,87494-13-1
N-tert-butyloxycarbonyl-S-trityl-L-cysteine

: 89028-35-3
N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-hydrazid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) N-methylmorpholin, HCl; 2) N-hydroxysuccinimid, DCCI / 1) methanol, 2 h; 2) 2 h, -5 deg C; 3 h, 0 deg C

2: 67 percent / hydrazine / methanol / 0.33 h / Heating

3: 1) tert-butylnitrit, HCl, N-methylmorpholine; 2) / 1) THF, methanol, 1 h, -30 deg C; 2) 1 h, -15 deg C, methanol, 3 h, -5 deg C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; tert.-butylnitrite; dicyclohexyl-carbodiimide; hydrazine; In methanol;

Reference yield:

: 21947-97-7
N-(t-butyloxycarbonyl)-S-(diphenylmethyl)-L-cysteine

: 89028-35-3
N-tert.-Butyloxycarbonyl-S-trityl-L-cysteinyl-S-diphenylmethyl-L-cysteinyl-L-alanyl-glycyl-L-valin-hydrazid

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / triethylamine, N-hydroxysuccinimide, DCCI / tetrahydrofuran; methanol / 1) 2 h, -5 deg C; 2) 2 h, 0 deg C

2: 1) N-methylmorpholin, HCl; 2) N-hydroxysuccinimid, DCCI / 1) methanol, 2 h; 2) 2 h, -5 deg C; 3 h, 0 deg C

3: 67 percent / hydrazine / methanol / 0.33 h / Heating

4: 1) tert-butylnitrit, HCl, N-methylmorpholine; 2) / 1) THF, methanol, 1 h, -30 deg C; 2) 1 h, -15 deg C, methanol, 3 h, -5 deg C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; tert.-butylnitrite; triethylamine; dicyclohexyl-carbodiimide; hydrazine; In tetrahydrofuran; methanol;