N-(4-carbamimidoylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Base Information

Chemical Name:N-(4-carbamimidoylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
CAS No.:1456890-24-6
Molecular Formula:C₁₅H₁₃N₅O₂S
Molecular Weight:327.367
Hs Code.:

Synonyms:N-(4-carbamimidoylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

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Chemical Property of N-(4-carbamimidoylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

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Technology Process of N-(4-carbamimidoylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

There total 3 articles about N-(4-carbamimidoylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

: 1104926-91-1
4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxylic acid

: 32797-61-8
4-(aminomethyl)benzenecarboximidamide

: 1456890-24-6
N-(4-carbamimidoylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm400718n

Reference yield:

: 844502-63-2
3-ethyl 4-methyl 2-aminothiophene-3,4-dicarboxylate

: 1456890-24-6
N-(4-carbamimidoylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 70 h / Inert atmosphere; Reflux

2: lithium hydroxide / water; methanol / 8 °C / Inert atmosphere

3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / N,N-dimethyl-formamide; ethyl acetate / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; lithium hydroxide; In methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm400718n

Reference yield:

: 1353498-44-8
ethyl 4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxylate

: 1456890-24-6
N-(4-carbamimidoylbenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / water; methanol / 8 °C / Inert atmosphere

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / N,N-dimethyl-formamide; ethyl acetate / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; lithium hydroxide; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm400718n