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32797-61-8

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32797-61-8 Usage

Description

4-Aminomethyl benzamidine dihydrochloride, also known as B5775, is a water-soluble chemical compound with the molecular formula C8H13Cl2N3. It is typically found as a white crystalline powder and is widely used in scientific and industrial applications, particularly in biochemistry. 4-AMINOMETHYL BENZAMIDINE DIHYDROCHLORIDE is recognized for its function as a damnacanthal mimetic and as an inhibitor of kinases and proteases, making it a valuable component in various research activities.

Uses

Used in Biochemical Research:
4-Aminomethyl benzamidine dihydrochloride is used as a research compound for its ability to mimic damnacanthal and inhibit the activity of kinases and proteases. This makes it a valuable tool in studying the mechanisms of these enzymes and their roles in various biological processes.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 4-Aminomethyl benzamidine dihydrochloride is used as a starting material or intermediate in the synthesis of potential drug candidates. Its properties as an enzyme inhibitor can be leveraged to develop new therapeutic agents targeting specific kinases or proteases, which are often implicated in various diseases.
Used in Chemical Synthesis:
4-Aminomethyl benzamidine dihydrochloride is employed as a reagent in the synthesis of other chemical compounds. Its unique structure and reactivity make it a useful building block in the creation of more complex molecules, which can be applied in various fields, including materials science and specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 32797-61-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,7,9 and 7 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 32797-61:
(7*3)+(6*2)+(5*7)+(4*9)+(3*7)+(2*6)+(1*1)=138
138 % 10 = 8
So 32797-61-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H11N3.2ClH/c9-5-6-1-3-7(4-2-6)8(10)11;;/h1-4H,5,9H2,(H3,10,11);2*1H

32797-61-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-AMINOMETHYL BENZAMIDINE DIHYDROCHLORIDE

1.2 Other means of identification

Product number -
Other names para-amidinobenzylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:32797-61-8 SDS

32797-61-8Relevant articles and documents

Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background-Free Amidation Reaction

Jaegle, Mike,Steinmetzer, Torsten,Rademann, J?rg

, p. 3718 - 3722 (2017)

Protein-templated reactions enable the target-guided formation of protein ligands from reactive fragments, ideally with no background reaction. Herein, we investigate the templated formation of amides. A nucleophilic fragment that binds to the coagulation factor Xa was incubated with the protein and thirteen differentially activated dipeptides. The protein induced a non-catalytic templated reaction for the phenyl and trifluoroethyl esters; the latter was shown to be a completely background-free reaction. Starting from two fragments with millimolar affinity, a 29 nm superadditive inhibitor of factor Xa was obtained. The fragment ligation reaction was detected with high sensitivity by an enzyme activity assay and by mass spectrometry. The reaction progress and autoinhibition of the templated reaction by the formed ligation product were determined, and the structure of the protein–inhibitor complex was elucidated.

Thrombin inhibitors having a lactam at P3

-

, (2008/06/13)

The present invention provides compounds having a lactam ring at P3 and at P1 have a six-membered heterocyclic ring having two ring nitrogen ring atoms and the remainder of the ring atoms carbon atoms. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.

Novel, potent non-covalent thrombin inhibitors incorporating P3-lactam scaffolds

Ho, Jonathan Z.,Gibson, Tony S.,Semple

, p. 743 - 748 (2007/10/03)

Evolution of P1-argininal inhibitor prototypes led to a series of non-covalent P3-7-membered lactam inhibitors 1a-w, featuring novel peptidomimetic units that probe each of the S1, S2, and S3 specificity pockets of thrombin. Rigid P1-arginine surrogates possessing a wide range of basicity (calcd pKa's~neutral-14) were surveyed. The design, synthesis, and biological activity of these targets are presented.

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