(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide

Base Information

Chemical Name:(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide
CAS No.:1326776-96-8
Molecular Formula:C₂₉H₃₅NO₂Si
Molecular Weight:457.688
Hs Code.:

Synonyms:(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide

Suppliers and Price of (S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide

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Technology Process of (S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide

There total 5 articles about (S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 64-18-6
formic acid

: 1326776-70-8
C₂₈H₃₅NOSi

: 1326776-96-8
(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide

Guidance literature:: With pyridine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo201215c

Reference yield:

: 1326776-46-8
(S)-(E)-methyl 4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpent-2-enoate

: 1326776-96-8
(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 5 h / -50 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

4.1: pyridine; dicyclohexyl-carbodiimide / dichloromethane / 4 h / 0 °C / Inert atmosphere

With pyridine; 1H-imidazole; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In hexane; dichloromethane;
DOI:10.1021/jo201215c

Reference yield:

: 1266130-89-5
(S)-(E)-tert-butyl (5-hydroxy-4-methyl-1-phenylpent-3-en-2-yl)carbamate

: 1326776-96-8
(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)formamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

3.1: pyridine; dicyclohexyl-carbodiimide / dichloromethane / 4 h / 0 °C / Inert atmosphere

With pyridine; 1H-imidazole; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo201215c