(2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide

Base Information

Chemical Name:(2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide
CAS No.:93623-00-8
Molecular Formula:C₁₆H₂₅BrNO₆P
Molecular Weight:438.255
Hs Code.:

Synonyms:(2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide

Suppliers and Price of (2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide

Chemical Property:

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Technology Process of (2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide

There total 3 articles about (2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 70702-03-3
(2S,3R)-2-Bromo-3-hydroxybutanoic acid

: 81439-58-9
diethyl ester of p-N-methoxyphenylaminomethylphosphonic acid

: 93623-00-8
(2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran;

Reference yield:

: 32752-37-7
1,3,5-tris(4-methoxyphenyl)-1,3,5-triazinane

: 93623-00-8
(2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / 6 h / 100 °C

2: 21 percent / DCC / tetrahydrofuran / 0.17 h / Ambient temperature

With dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1246/bcsj.60.645

Reference yield:

: 104-94-9
4-methoxy-aniline

: 93623-00-8
(2S,3R)-N-(diethoxyphosphinylmethyl)-N-(4-methoxyphenyl)-2-bromo-3-hydroxybutyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / ethanol; H₂O / 0.25 h / Ambient temperature

2: 61 percent / 6 h / 100 °C

3: 21 percent / DCC / tetrahydrofuran / 0.17 h / Ambient temperature

With dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; water;
DOI:10.1246/bcsj.60.645