3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide

Base Information

Chemical Name:3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide
CAS No.:1198621-02-1
Molecular Formula:C₁₅H₁₃ClFN₃O₄
Molecular Weight:353.737
Hs Code.:

Synonyms:3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide

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Chemical Property of 3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide

Chemical Property:

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Technology Process of 3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide

There total 10 articles about 3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₆ClFN₂O₅

: 1198621-02-1
3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide

Guidance literature:: With pyridine; hydroxylamine; In water; at 45 ℃; for 1h;

Reference yield:

: 1198621-14-5
methyl 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate

: 1198621-02-1
3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide

Guidance literature:: Multi-step reaction with 8 steps

1: formic acid / 1 h / 20 °C

2: triethylamine / dmap / dichloromethane / 3 h

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h

4: trifluoroacetic acid / tripropylsilane / dichloromethane

5: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / Reflux

6: sodium chlorite; sodium dihydrogenphosphate; 2-Methyl-1-butene / tetrahydrofuran; water; acetone / 0.33 h / 20 °C

7: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1 h

8: pyridine; hydroxylamine / water / 1 h / 45 °C

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; formic acid; hydrogen; hydroxylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 2-Methyl-1-butene; triethylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dmap; tripropylsilane; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone;

Reference yield:

: 1198621-15-6
methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate

: 1198621-02-1
3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dmap / dichloromethane / 3 h

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 3 h

3: trifluoroacetic acid / tripropylsilane / dichloromethane

4: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / Reflux

5: sodium chlorite; sodium dihydrogenphosphate; 2-Methyl-1-butene / tetrahydrofuran; water; acetone / 0.33 h / 20 °C

6: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1 h

7: pyridine; hydroxylamine / water / 1 h / 45 °C

With 4-methyl-morpholine; pyridine; sodium chlorite; sodium dihydrogenphosphate; hydrogen; hydroxylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 2-Methyl-1-butene; triethylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; dmap; tripropylsilane; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone;