3-Benzofurancarboxylicacid,5-fluoro-2-methyl-,ethylester(9CI)

Base Information

• Chemical Name: 3-Benzofurancarboxylicacid,5-fluoro-2-methyl-,ethylester(9CI)
• CAS No.: 826990-64-1
• Molecular Formula: C₁₂H₁₁FO₃
• Molecular Weight: 222.216
• Mol file: 826990-64-1.mol

Synonyms:3-Benzofurancarboxylicacid,5-fluoro-2-methyl-,ethylester(9CI)

Chemical Property of 3-Benzofurancarboxylicacid,5-fluoro-2-methyl-,ethylester(9CI)

Chemical Property:

• PSA: 39.44000
• LogP: 3.05700

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Benzofurancarboxylicacid,5-fluoro-2-methyl-,ethylester(9CI)

There total 4 articles about 3-Benzofurancarboxylicacid,5-fluoro-2-methyl-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl acetoacetate (141-97-9) + 1-bromo-4-fluoro-2-iodobenzene (202865-72-3) → ethyl 5-fluoro-2-methylbenzofuran-3-carboxylate (826990-64-1)

Guidance literature:

With potassium carbonate; copper(l) iodide; In tetrahydrofuran; at 100 ℃; for 24h;

DOI:10.1021/jo070729r

Reference yield: 71.0%

[(4-fluorophenoxyacetyl)(ethoxycarbonyl)methylene]triphenylphosphorane (826990-54-9) → ethyl 5-fluoro-2-methylbenzofuran-3-carboxylate (826990-64-1)

Guidance literature:

for 0.116667h; microwave irradiation;

DOI:10.1016/j.tet.2004.10.019

Reference yield: 63.0%

ethyl 2-diazo-3-oxobutanoate (2009-97-4) + 5-fluoro-2-hydroxybenzaldehyde (347-54-6) → ethyl 5-fluoro-2-methylbenzofuran-3-carboxylate (826990-64-1)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) triflimide; In 1,2-dichloro-ethane; at 50 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.6b03355

upstream raw materials:

[(4-fluorophenoxyacetyl)(ethoxycarbonyl)methylene]triphenylphosphorane

ethyl acetoacetate

1-bromo-4-fluoro-2-iodobenzene

ethyl 2-diazo-3-oxobutanoate