2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile

Base Information

Chemical Name:2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile
CAS No.:1274905-21-3
Molecular Formula:C₂₁H₂₂BrClFNO
Molecular Weight:438.767
Hs Code.:

Synonyms:2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile

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Technology Process of 2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile

There total 5 articles about 2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1274905-18-8
2-(2-chloro-5-hydroxyphenyl)-2-isopropyl-3-methylbutanenitrile

: 112399-50-5
2-bromo-5-fluorobenzyl bromide

: 1274905-21-3
2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile

Guidance literature:: With potassium carbonate; In acetone; at 50 ℃;
DOI:10.1021/ol200329e

Reference yield:

: 3771-13-9
2-(bromomethyl)-1-chloro-4-methoxybenzene

: 1274905-21-3
2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 0 - 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

3: boron tribromide / dichloromethane / 0 - 20 °C

4: potassium carbonate / acetone / 50 °C

With tetrabutyl ammonium fluoride; boron tribromide; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1021/ol200329e

Reference yield:

: 1274905-17-7
2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile

: 1274905-21-3
2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 0 - 20 °C

2: potassium carbonate / acetone / 50 °C

With boron tribromide; potassium carbonate; In dichloromethane; acetone;
DOI:10.1021/ol200329e