2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile

Base Information

• Chemical Name: 2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile
• CAS No.: 1274905-17-7
• Molecular Formula: C₁₅H₂₀ClNO
• Molecular Weight: 265.783
• Mol file: 1274905-17-7.mol

Synonyms:2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile

Chemical Property of 2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile

There total 3 articles about 2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-iodo-propane (75-30-9) + 2-(2-chloro-5-methoxyphenyl)acetonitrile (90537-17-0) → 2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile (1274905-17-7)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ol200329e

Reference yield:

1-chloro-4-methoxy-2-methylbenzene (13334-71-9) → 2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile (1274905-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 80 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 0 - 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; acetonitrile;

DOI:10.1021/ol200329e

Reference yield:

2-(bromomethyl)-1-chloro-4-methoxybenzene (3771-13-9) → 2-(2-chloro-5-methoxyphenyl)-2-isopropyl-3-methylbutanenitrile (1274905-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 0 - 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

With tetrabutyl ammonium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ol200329e

upstream raw materials:

2-iodo-propane

2-(2-chloro-5-methoxyphenyl)acetonitrile

2-(bromomethyl)-1-chloro-4-methoxybenzene

1-chloro-4-methoxy-2-methylbenzene

Downstream raw materials:

2-(2-chloro-5-hydroxyphenyl)-2-isopropyl-3-methylbutanenitrile

2-(5-((2-bromobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile

2-(2-chloro-((2-chlorobenzyl)oxy)phenyl)-2-isopropyl-3-methylbutanenitrile

2-(5-((2-bromo-5-fluorobenzyl)oxy)-2-chlorophenyl)-2-isopropyl-3-methylbutanenitrile

Refernces