methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate

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Chemical Name:methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate
CAS No.:1093098-95-3
Molecular Formula:C₂₂H₃₀N₄O₅S
Molecular Weight:462.57
Hs Code.:

Synonyms:methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate

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Chemical Property of methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate

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Technology Process of methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate

There total 6 articles about methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1093098-94-2
methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-cyanophenyl)-1H-imidazol-2-yl) propanoate

: 1093098-95-3
methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate

Guidance literature:: With ammonium sulfide; water; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol8022962

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1093098-95-3
methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hexamethylsilazane / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

2: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 48 h / 130 °C / Inert atmosphere

3: ammonium sulfide / ethanol / 2 h / 90 °C / Inert atmosphere

With copper(l) iodide; ammonium sulfide; potassium hexamethylsilazane; potassium carbonate; L-proline; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.11.070

Reference yield:

: methyl 3-(1H-imidazol-2-yl)propanoate hydrochloride

: 1093098-95-3
methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 48 h / 130 °C / Inert atmosphere

2: ammonium sulfide / ethanol / 2 h / 90 °C / Inert atmosphere

With copper(l) iodide; ammonium sulfide; potassium carbonate; L-proline; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.11.070