methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate

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Chemical Name:methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate
CAS No.:1093098-96-4
Molecular Formula:C₂₇H₃₆N₄O₆S
Molecular Weight:544.672
Hs Code.:

Synonyms:methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate

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Chemical Property of methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate

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Technology Process of methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate

There total 7 articles about methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 105-48-6
isopropyl chloroacetate

: 1093098-95-3
methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate

: 1093098-96-4
methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate

Guidance literature:: In isopropyl alcohol; at 20 - 80 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol8022962

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1093098-96-4
methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hexamethylsilazane / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

2: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 48 h / 130 °C / Inert atmosphere

3: ammonium sulfide / ethanol / 2 h / 90 °C / Inert atmosphere

4: ethanol / 2 h / 80 °C / Inert atmosphere

With copper(l) iodide; ammonium sulfide; potassium hexamethylsilazane; potassium carbonate; L-proline; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.11.070

Reference yield:

: 1093098-94-2
methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-cyanophenyl)-1H-imidazol-2-yl) propanoate

: 1093098-96-4
methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium sulfide / ethanol / 2 h / 90 °C / Inert atmosphere

2: ethanol / 2 h / 80 °C / Inert atmosphere

With ammonium sulfide; In ethanol;
DOI:10.1016/j.tet.2012.11.070