N-(2,4-difluoro-3-(5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(2,4-difluoro-3-(5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide
CAS No.:1402558-50-2
Molecular Formula:C₂₆H₂₈F₂N₆O₃S
Molecular Weight:542.61
Hs Code.:

Synonyms:N-(2,4-difluoro-3-(5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

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Chemical Property of N-(2,4-difluoro-3-(5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

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Technology Process of N-(2,4-difluoro-3-(5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

There total 4 articles about N-(2,4-difluoro-3-(5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918504-27-5
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide

: 1402558-50-2
N-(2,4-difluoro-3-(5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 0.03 h / 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Suzuki Coupling;

Reference yield:

: 1312940-04-7
propane-1-sulfonic acid {2,4-difluoro-3-[5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-amide

: 74-88-4
methyl iodide

: 1402558-50-2
N-(2,4-difluoro-3-(5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 877399-74-1
tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1402558-50-2
N-(2,4-difluoro-3-(5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; dimethyl sulfoxide / 0.03 h / 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Suzuki Coupling;