8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline

Base Information

Chemical Name:8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline
CAS No.:160857-67-0
Molecular Formula:C₂₅H₂₃BrN₂O₅
Molecular Weight:511.372
Hs Code.:

Synonyms:8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline

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Chemical Property of 8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline

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Technology Process of 8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline

There total 12 articles about 8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 160857-72-7
(4-methoxy-3-nitrophenyl)ketene

: 160857-70-5
(3-benzyloxy-6-bromo-4-methoxyphenethylimino)triphenylphosphorane

: 160857-67-0
8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline

Guidance literature:: In toluene; 0 deg C, 2 h then 75 deg C, 14 h;
DOI:10.1016/0040-4039(94)02211-S

Reference yield:

: 141035-23-6
5-Benzyloxy-2-brom-4-methoxy-phenaethylamin

: 160857-67-0
8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / CCl₄ / CH₂Cl₂ / 72 h / 40 °C

2: 95 percent / sodium amide / toluene / 1 h / 100 °C

3: 78 percent / toluene / 14 h / 75 °C

With tetrachloromethane; sodium amide; In dichloromethane; toluene; 3: aza-Wittig reaction;
DOI:10.1021/jo030287t

Reference yield:

: 904-42-7
2-Phenyl-4-(3-nitro-4-methoxy-benzyliden)-4H-(1,3)-oxazol-5-on

: 160857-67-0
8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaOH / 90 °C

1.2: 80 percent / H₂O₂

2.1: 720 mg / Mitsunobu conditions

3.1: 78 percent / toluene / 14 h / 75 °C

With sodium hydroxide; In toluene; 4.1: aza-Wittig reaction;
DOI:10.1021/jo030287t