4-{2-[(2,2-diphenyl-ethyl)-amino]-5-{[4-[4-(1-methyl-ethyl)-piperazin-1-yl-carbonyl]-piperidin-1-yl]-sulfonyl}-benzoyl}-morpholine

Base Information

Chemical Name:4-{2-[(2,2-diphenyl-ethyl)-amino]-5-{[4-[4-(1-methyl-ethyl)-piperazin-1-yl-carbonyl]-piperidin-1-yl]-sulfonyl}-benzoyl}-morpholine
CAS No.:312722-59-1
Molecular Formula:C₃₈H₄₉N₅O₅S
Molecular Weight:687.904
Hs Code.:

Synonyms:4-{2-[(2,2-diphenyl-ethyl)-amino]-5-{[4-[4-(1-methyl-ethyl)-piperazin-1-yl-carbonyl]-piperidin-1-yl]-sulfonyl}-benzoyl}-morpholine

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Chemical Property of 4-{2-[(2,2-diphenyl-ethyl)-amino]-5-{[4-[4-(1-methyl-ethyl)-piperazin-1-yl-carbonyl]-piperidin-1-yl]-sulfonyl}-benzoyl}-morpholine

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Technology Process of 4-{2-[(2,2-diphenyl-ethyl)-amino]-5-{[4-[4-(1-methyl-ethyl)-piperazin-1-yl-carbonyl]-piperidin-1-yl]-sulfonyl}-benzoyl}-morpholine

There total 7 articles about 4-{2-[(2,2-diphenyl-ethyl)-amino]-5-{[4-[4-(1-methyl-ethyl)-piperazin-1-yl-carbonyl]-piperidin-1-yl]-sulfonyl}-benzoyl}-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4318-42-7
1-(1-methylethyl)piperazine

: C₃₁H₃₄ClN₃O₅S

: 312722-59-1
4-{2-[(2,2-diphenyl-ethyl)-amino]-5-{[4-[4-(1-methyl-ethyl)-piperazin-1-yl-carbonyl]-piperidin-1-yl]-sulfonyl}-benzoyl}-morpholine

Guidance literature:: With triethylamine; In dichloromethane; at -10 ℃; for 1h;

Reference yield:

: 4318-42-7
1-(1-methylethyl)piperazine

: 752243-41-7
{2-(2,2-diphenyl-ethylamino)-5-[4-(4-carboxy)-piperidine-1-sulfonyl]-phenyl}-morpholin-4-yl-methanone

: 312722-59-1
4-{2-[(2,2-diphenyl-ethyl)-amino]-5-{[4-[4-(1-methyl-ethyl)-piperazin-1-yl-carbonyl]-piperidin-1-yl]-sulfonyl}-benzoyl}-morpholine

Guidance literature:: {2-(2,2-diphenyl-ethylamino)-5-[4-(4-carboxy)-piperidine-1-sulfonyl]-phenyl}-morpholin-4-yl-methanone; With 4-methyl-morpholine; isopropyl chloroformate; In tetrahydrofuran; at -40 ℃; for 0.666667h;

1-(1-methylethyl)piperazine; In tetrahydrofuran;
DOI:10.1021/jm049747g

Reference yield:

: 7304-32-7
2-fluoro-5-nitrobenzoic acid

: 312722-59-1
4-{2-[(2,2-diphenyl-ethyl)-amino]-5-{[4-[4-(1-methyl-ethyl)-piperazin-1-yl-carbonyl]-piperidin-1-yl]-sulfonyl}-benzoyl}-morpholine

Guidance literature:: Multi-step reaction with 6 steps

1.1: (COCl)2 / toluene; dimethylformamide / 20 °C

2.1: Et₃N / tetrahydrofuran

3.1: Zn; AcOH

4.1: NaNO₂; HCl; AcOH

4.2: SO₂; CuCl₂; aq. AcOH

4.3: aq. Na₂CO₃ / dioxane

5.1: dimethylsulfoxide / 120 °C

6.1: isopropyl chloroformate; NMM / tetrahydrofuran / 0.67 h / -40 °C

6.2: tetrahydrofuran

With 4-methyl-morpholine; hydrogenchloride; oxalyl dichloride; acetic acid; isopropyl chloroformate; triethylamine; zinc; sodium nitrite; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm049747g