2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide

Base Information

Chemical Name:2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide
CAS No.:1290608-32-0
Molecular Formula:C₁₅H₁₃ClF₃N₃O₂
Molecular Weight:359.735
Hs Code.:

Synonyms:2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide

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Chemical Property of 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide

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Technology Process of 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide

There total 3 articles about 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 56934-53-3
2-amino-6-methoxy-N-methylbenzamide

: 505084-55-9
2-chloro-4-iodo-5-(trifluoromethyl)pyridine

: 1290608-32-0
2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; for 5h; regioselective reaction; Inert atmosphere;
DOI:10.1080/00397911.2010.520403

Reference yield:

: 53600-33-2
6-methoxyanthranilic acid

: 1290608-32-0
2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; toluene / 10 - 20 °C

2: water / 5 - 20 °C

3: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 5 h / 90 °C / Inert atmosphere

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 1,4-dioxane; water; toluene; 3: Buchwald-Hartwig reaction;
DOI:10.1080/00397911.2010.520403

Reference yield:

: 67765-42-8
5-methoxy-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione

: 1290608-32-0
2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: water / 5 - 20 °C

2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 5 h / 90 °C / Inert atmosphere

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; 2: Buchwald-Hartwig reaction;
DOI:10.1080/00397911.2010.520403