C₂₈H₄₉NO₆Si

Base Information

• Chemical Name: C₂₈H₄₉NO₆Si
• CAS No.: 1414941-34-6
• Molecular Formula: C₂₈H₄₉NO₆Si
• Molecular Weight: 523.786
• Mol file: 1414941-34-6.mol

Synonyms:C₂₈H₄₉NO₆Si

Chemical Property of C₂₈H₄₉NO₆Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₄₉NO₆Si

There total 10 articles about C₂₈H₄₉NO₆Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2R,3S)-2-amino-3-methoxyhex-5-en-1-ol (1351977-01-9) + (S)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-4,4-dimethylpentanoic acid (1414941-23-3) → C28H49NO6Si (1414941-34-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/chem.201302197

Reference yield:

3-[(4-methoxyphenyl)methoxy]-2,2-dimethyl-propan-1-ol (446264-36-4) → C28H49NO6Si (1414941-34-6)

Guidance literature:

Multi-step reaction with 5 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; caesium carbonate; (S)-(-)-5,5'-dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl; 4-chloro-3-nitrobenzoate / tetrahydrofuran / Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

3: Sudan III; ozone; triphenylphosphine / dichloromethane / 2 h / -78 - 20 °C

4: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1.5 h / 20 °C / Inert atmosphere

5: triethylamine / tetrahydrofuran / 20 °C

With 2,6-dimethylpyridine; sodium dihydrogenphosphate; (S)-(-)-5,5'-dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl; bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium chlorite; caesium carbonate; ozone; triethylamine; triphenylphosphine; 4-chloro-3-nitrobenzoate; Sudan III; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;

DOI:10.1002/chem.201302197

Reference yield:

methyl 2-(2-(4-methoxybenzyloxy)ethyl)oxazole-4-carboxylate (1414941-33-5) → C28H49NO6Si (1414941-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1.5 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 20 °C

With sodium dihydrogenphosphate; sodium chlorite; triethylamine; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1002/chem.201302197

upstream raw materials:

3-[(4-methoxyphenyl)methoxy]-2,2-dimethyl-propan-1-ol

1-(4-methoxy-benzyloxy)-2,2-dimethyl-hex-5-en-3-ol

(S)-tert-butyl(1-(4-methoxybenzyloxy)-2,2-dimethylhex-5-en-3-yloxy)dimethylsilane

methyl 2-(2-(4-methoxybenzyloxy)ethyl)oxazole-4-carboxylate

Downstream raw materials:

C₂₈H₄₇NO₆Si

C₂₈H₄₅NO₅Si

C₃₃H₅₅NO₇Si

(2S,5S,7S)-7-[(tert-butyldimethylsilyl)oxy]-5-hydroxy-1-[(4-methoxybenzyl)oxy]-8-{4-[(S)-1-methoxybut-3-en-1-yl]oxazol-2-yl}-2,6,6-trimethyloctan-3-one