3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol

Base Information

• Chemical Name: 3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol
• CAS No.: 197959-71-0
• Molecular Formula: C₁₆H₁₆Cl₂O₅S
• Molecular Weight: 391.272
• Mol file: 197959-71-0.mol

Synonyms:3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol

Chemical Property of 3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol

There total 4 articles about 3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,3-dichlorobenzenesulfonic acid 3-hydroxy-5-methylphenyl ester (189341-21-7) + trimethyleneglycol (504-63-2) → 3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol (197959-71-0)

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 20 ℃;

Reference yield: 88.0%

1,1'-(Azodicarbonyl)dipiperidin (10465-81-3,871024-86-1) + 2,3-dichlorobenzenesulfonic acid 3-hydroxy-5-methylphenyl ester (189341-21-7) + trimethyleneglycol (504-63-2) → 3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol (197959-71-0)

Guidance literature:

With tributylphosphine; In tetrahydrofuran; hexane;

Reference yield:

orcinol (504-15-4) → 3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol (197959-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaHCO₃ / diethyl ether

2: PBu₃; ADDP

With tributylphosphine; sodium hydrogencarbonate; 1,1'-azodicarbonyl-dipiperidine; In diethyl ether; 1: Sulfonylation / 2: Condensation;

DOI:10.1016/S0960-894X(99)00632-0

upstream raw materials:

2,3-dichlorobenzenesulfonic acid 3-hydroxy-5-methylphenyl ester

trimethyleneglycol

orcinol

dichlorobenzenesulfonyl chloride

Downstream raw materials:

3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]-propionaldehyde

3-[3-(3-Chlorophenylsulfonyloxy)-5-methylphenoxy]propionaldehyde