(2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol

Base Information

Chemical Name:(2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol
CAS No.:108030-68-8
Molecular Formula:C₁₅H₂₁F₃O
Molecular Weight:274.326
Hs Code.:

Synonyms:(2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol

Suppliers and Price of (2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol

There total 16 articles about (2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 108030-67-7
(2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dienoic acid methyl ester

: 108030-68-8
(2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; at -78 ℃; for 1h;
DOI:10.1016/S0040-4039(00)95054-8

Reference yield:

: 1,1,1-Trifluoro-5-(tetrahydro-pyran-2-yloxy)-pent-3-yn-2-ol

: 108030-68-8
(2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol

Guidance literature:: Multi-step reaction with 12 steps

1: hydrogen / PtO₂ / methanol

2: 2,6-lutidune / CH₂Cl₂

3: 85 percent / p-TsOH / methanol

4: LiBr / acetone

5: 1.) Mg 2.) 3P>4 / THF

6: n-BuF₄ / tetrahydrofuran

7: Na₂Cr₂O₇*2H₂O, H₂SO₄ / acetic acid / Ambient temperature

8: 78 percent / LiH / tetrahydrofuran; hexamethylphosphoric acid triamide / 48 h / Heating

9: 73 percent / DIBAL-H / hexane / 24 h / -78 °C

10: 94 percent / MnO₂ / CH₂Cl₂ / 3 h / Ambient temperature

11: 1.) n-BuLi / 1.) THF, -78 deg C 2.) room temperature, 10 h

12: 94 percent / DIBAL-H / hexane / 1 h / -78 °C

With 2,6-dimethylpyridine; manganese(IV) oxide; n-butyllithium; sodium dichromate; tetrakiscopper(I); sulfuric acid; hydrogen; lithium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; magnesium; lithium bromide; platinum(IV) oxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; acetic acid; acetone;
DOI:10.1016/S0040-4039(00)95054-8

Reference yield:

: 245069-30-1
1,1,1-trifluoro-5-[(tetrahydro-2H-pyran-2-yl)oxy]-3-pentyn-2-one

: 108030-68-8
(2E,4E)-5-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3-methyl-penta-2,4-dien-1-ol

Guidance literature:: Multi-step reaction with 13 steps

1: 90.3 percent / NaBH₄ / ethanol

2: hydrogen / PtO₂ / methanol

3: 2,6-lutidune / CH₂Cl₂

4: 85 percent / p-TsOH / methanol

5: LiBr / acetone

6: 1.) Mg 2.) 3P>4 / THF

7: n-BuF₄ / tetrahydrofuran

8: Na₂Cr₂O₇*2H₂O, H₂SO₄ / acetic acid / Ambient temperature

9: 78 percent / LiH / tetrahydrofuran; hexamethylphosphoric acid triamide / 48 h / Heating

10: 73 percent / DIBAL-H / hexane / 24 h / -78 °C

11: 94 percent / MnO₂ / CH₂Cl₂ / 3 h / Ambient temperature

12: 1.) n-BuLi / 1.) THF, -78 deg C 2.) room temperature, 10 h

13: 94 percent / DIBAL-H / hexane / 1 h / -78 °C

With 2,6-dimethylpyridine; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; sodium dichromate; tetrakiscopper(I); sulfuric acid; hydrogen; lithium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; magnesium; lithium bromide; platinum(IV) oxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; dichloromethane; acetic acid; acetone;
DOI:10.1016/S0040-4039(00)95054-8