3-<2-cyano-2,2-bis(4-fluorophenyl)ethyl>-1-pyrrolidinecarboxylic acid phenyl ester

Base Information

Chemical Name:3-<2-cyano-2,2-bis(4-fluorophenyl)ethyl>-1-pyrrolidinecarboxylic acid phenyl ester
CAS No.:135256-93-8
Molecular Formula:C₂₆H₂₂F₂N₂O₂
Molecular Weight:432.47
Hs Code.:

Synonyms:3-<2-cyano-2,2-bis(4-fluorophenyl)ethyl>-1-pyrrolidinecarboxylic acid phenyl ester

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Chemical Property of 3-<2-cyano-2,2-bis(4-fluorophenyl)ethyl>-1-pyrrolidinecarboxylic acid phenyl ester

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Technology Process of 3-<2-cyano-2,2-bis(4-fluorophenyl)ethyl>-1-pyrrolidinecarboxylic acid phenyl ester

There total 3 articles about 3-<2-cyano-2,2-bis(4-fluorophenyl)ethyl>-1-pyrrolidinecarboxylic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 111952-52-4
α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidineacetonitrile

: 1885-14-9
phenyl chloroformate

: 135256-93-8
3-<2-cyano-2,2-bis(4-fluorophenyl)ethyl>-1-pyrrolidinecarboxylic acid phenyl ester

Guidance literature:: With potassium hydrogencarbonate; In dichloromethane; Heating;
DOI:10.1021/jm00114a009

Reference yield:

: 37742-99-7
4-fluoro-α-(4-fluorophenyl)benzeneacetonitrile

: 135256-93-8
3-<2-cyano-2,2-bis(4-fluorophenyl)ethyl>-1-pyrrolidinecarboxylic acid phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMSO, RT, 3 h, 2.) DMSO, 60 deg C, overnight

2: 70 percent / KHCO₃ / CH₂Cl₂ / Heating

With sodium hydride; potassium hydrogencarbonate; In dichloromethane;
DOI:10.1021/jm00114a009

Reference yield:

: 111627-59-9
1-(phenylmethyl)-3-pyrrolidinemethanol 4-methylbenzenesulfonate ester ethanedioate

: 135256-93-8
3-<2-cyano-2,2-bis(4-fluorophenyl)ethyl>-1-pyrrolidinecarboxylic acid phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMSO, RT, 3 h, 2.) DMSO, 60 deg C, overnight

2: 70 percent / KHCO₃ / CH₂Cl₂ / Heating

With sodium hydride; potassium hydrogencarbonate; In dichloromethane;
DOI:10.1021/jm00114a009