Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine

Base Information

• Chemical Name: Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine
• CAS No.: 306961-72-8
• Molecular Formula: C₂₁H₂₉NOSi
• Molecular Weight: 339.553
• Mol file: 306961-72-8.mol

Synonyms:Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine

Chemical Property of Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine

There total 6 articles about Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(tert-butyldimethylsilyloxy)-2-phenylacetaldehyde (163667-14-9) + benzylamine (100-46-9) → Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine (306961-72-8)

Guidance literature:

With magnesium sulfate; In toluene;

DOI:10.1021/jo005509r

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine (306961-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole / dimethylformamide

2: 86 percent / DIBALH / diethyl ether / -78 °C

3: MgSO₄ / toluene

With 1H-imidazole; diisobutylaluminium hydride; magnesium sulfate; In diethyl ether; N,N-dimethyl-formamide; toluene; 1: Condensation / 2: Reduction / 3: Condensation;

DOI:10.1021/jo005509r

Reference yield:

(tert-Butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester (135348-18-4) → Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine (306961-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / DIBALH / diethyl ether / -78 °C

2: MgSO₄ / toluene

With diisobutylaluminium hydride; magnesium sulfate; In diethyl ether; toluene; 1: Reduction / 2: Condensation;

DOI:10.1021/jo005509r

upstream raw materials:

benzylamine

2-(tert-butyldimethylsilyloxy)-2-phenylacetaldehyde

tert-butyldimethylsilyl chloride

(tert-Butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester

Downstream raw materials:

2-benzylamino-1-phenyl-ethanol

2-(Benzylamino)-1-<(tert-butyldimethylsilyl)oxy>-1-phenylethane