9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

Base Information

Chemical Name:9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine
CAS No.:306305-11-3
Molecular Formula:C₃₂H₄₀N₆O₃Si
Molecular Weight:584.793
Hs Code.:

Synonyms:9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

There total 4 articles about 9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055039-87-6
thiocarbonic acid O-[4-benzyloxy-5-benzyloxymethyl-2-(2,6-diamino-purin-9-yl)-5-triethylsilanylethynyl-tetrahydro-furan-3-yl] ester O-phenyl ester

: 306305-11-3
9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 85 ℃; for 1h;
DOI:10.1021/jm000209n

Reference yield:

: 1904-98-9
2,6-diaminopurine

: 306305-11-3
9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 25.5 h / Heating

2: 93 percent / triethylamine; methanol / 24 h / 20 °C

3: 4-(dimethylamino)pyridine / acetonitrile / 1 h / 20 °C

4: 2,2'-azobis(isobutyronitrile); tri-n-butyltin hydride / toluene / 1 h / 85 °C

With methanol; dmap; N,O-bis-(trimethylsilyl)-acetamide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tri-n-butyl-tin hydride; triethylamine; In 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/jm000209n

Reference yield:

: 233266-82-5
1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-D-ribo-pentofuranose

: 306305-11-3
9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 25.5 h / Heating

2: 93 percent / triethylamine; methanol / 24 h / 20 °C

3: 4-(dimethylamino)pyridine / acetonitrile / 1 h / 20 °C

4: 2,2'-azobis(isobutyronitrile); tri-n-butyltin hydride / toluene / 1 h / 85 °C

With methanol; dmap; N,O-bis-(trimethylsilyl)-acetamide; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; tri-n-butyl-tin hydride; triethylamine; In 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1021/jm000209n