9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

Base Information

• Chemical Name: 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine
• CAS No.: 306305-09-9
• Molecular Formula: C₃₄H₄₂N₆O₅Si
• Molecular Weight: 642.83

Synonyms:9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

Chemical Property of 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

There total 2 articles about 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2,6-diaminopurine (1904-98-9) + 1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-D-ribo-pentofuranose (233266-82-5) → 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine (306305-09-9)

Guidance literature:

With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 25.5h; Heating;

DOI:10.1021/jm000209n

Reference yield:

9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine (306305-11-3) → 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine (306305-09-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

Reference yield: 93.0%

9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine (306305-09-9) → 9-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine (306305-10-2)

Guidance literature:

With methanol; triethylamine; at 20 ℃; for 24h;

DOI:10.1021/jm000209n

upstream raw materials:

2,6-diaminopurine

1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-D-ribo-pentofuranose

9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

Downstream raw materials:

9-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

9-(3,5-di-O-benzyl-2-deoxy-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)-2,6-diaminopurine

thiocarbonic acid O-[4-benzyloxy-5-benzyloxymethyl-2-(2,6-diamino-purin-9-yl)-5-triethylsilanylethynyl-tetrahydro-furan-3-yl] ester O-phenyl ester

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