(2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester

Base Information

Chemical Name:(2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester
CAS No.:883148-15-0
Molecular Formula:C₁₄H₁₉NO₅
Molecular Weight:281.309
Hs Code.:

Synonyms:(2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester

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Chemical Property of (2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester

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Technology Process of (2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester

There total 5 articles about (2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (2R,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester hydrochloride

: 541-41-3
chloroformic acid ethyl ester

: 883148-15-0
(2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; for 2h;
DOI:10.1021/jo0525579

Reference yield:

: 147976-17-8
(4S,5R)-4-benzyl-2-oxazolidinone-5-carboxylic acid methyl ester

: 883148-15-0
(2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester

Guidance literature:: (4S,5R)-4-benzyl-2-oxazolidinone-5-carboxylic acid methyl ester; With methanesulfonyl chloride; triethylamine; at 0 ℃; for 2.16667h;

With N,N-dimethyl-formamide; In water; toluene; at 85 ℃; for 12h; pH=4 - 9;

Reference yield:

: 116565-10-7
(2R,3S)-N-(tert-butoxycarbonyl)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

: 883148-15-0
(2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 1 h / 20 °C

2: 12.0 mg / HCl; anisole / dioxane / 0.5 h / 20 °C

3: 99 percent Chromat_. / phosphate buffered saline / 1 h / 25 °C / pH 7.4

With pyridine; hydrogenchloride; phosphate buffered saline; methoxybenzene; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo0525579