147976-17-8

Upstream product

• 75-44-5 phosgene 
• 209174-37-8 3(S)-amino-2(R,S)-hydroxy-4-phenylbutyric acid methyl ester 
• 530-62-1 1,1'-carbonyldiimidazole 
• 116565-10-7 (2R,3S)-N-(tert-butoxycarbonyl)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 
• 412941-09-4 4-benzyl-3-benzyloxycarbonylamino-2-oxazolidinone-5-carboxylic acid methyl ester 
• 1027661-56-8 C₂₈H₂₈N₂O₇ 
• 412941-20-9 C₂₈H₃₀N₂O₇ 
• 72155-45-4 Boc-L-phenylalaninal 
• 211676-28-7 1-(S)-cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl benzoate 
• 176751-64-7 (2S,3S)-3-(ethoxycarbonyl)amino-2-hydroxy-4-phenylbutyric acid methyl ester 

Downstream Products

• 383398-38-7 (2R,3S)-3-ethylamino-2-hydroxy-4-phenylbutyric acid 
• 62023-63-6 (2R,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid 
• 883148-15-0 (2R,3S)-3-[(ethoxycarbonyl)amino]-2-hydroxy-4-phenylbutanoic acid methyl ester 

Relevant academic research and scientific papers

O-N intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids

O-N Intramolecular alkoxycarbonyl (carbonate-carbamate) migration was found to occur as a common reaction of hydroxyamino acids under mild basic aqueous conditions with no formation of side products. Carbonate protective groups migrate to produce amino-pr

PROCESSES FOR PRODUCING OXAZOLIDINONE DERIVATIVE OF BETA-HYDROXYETHYLAMINE COMPOUND AND FOR PRODUCING BETA-HYDROXYETHYLAMINE COMPOUND

The present invention provides a process of starting from N-alkoxycarbonyl-ethylamine compounds having a leaving group at the β-position to prepare oxazolidinone derivatives of β-hydroxyethylamine compounds having an inverted steric configuration at the β

Catalytic asymmetric direct α-amination reactions of 2-keto esters: A simple synthetic approach to optically active syn-β-amino-α-hydroxy esters

The catalytic enantioselective direct α-amination reaction of 2-keto esters with easily available azo dicarboxylates as the nitrogen source and chiral bisoxazoline-copper(II) complexes as the catalyst is presented. The reations proceed with excellent enan

A concise synthesis of aza-dipeptide isosteres

Aza-dipeptide isosteres as potent HIV-protease inhibitors containing a (hydroxyethyl)-hydrazine moiety are synthesised in >98% diastereomeric and enantiomeric purity starting from (L)-phenylalanine aldehyde.

Process for the manufacture of (4,5)-trans-oxazolidines

Compounds containing a (4,5)-cis-2-oxo-oxazolidine ring are isomerized to the corresponding (4,5)-trans-2-oxo-oxazolidine by treating the cis compound with a strong base.