N-(4-((2-hydroxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-(4-((2-hydroxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:1374007-10-9
Molecular Formula:C₁₈H₁₄F₃N₃O₄S
Molecular Weight:425.388
Hs Code.:

Synonyms:N-(4-((2-hydroxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-((2-hydroxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of N-(4-((2-hydroxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 6 articles about N-(4-((2-hydroxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1374007-09-6
N-(4-((2-methoxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

: 1374007-10-9
N-(4-((2-hydroxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With boron tribromide; In dichloromethane;
DOI:10.1021/jm201699w

Reference yield:

: 73015-47-1
(2-methoxyphenyl)(4-nitrophenyl)sulfane

: 1374007-10-9
N-(4-((2-hydroxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate / methanol; dichloromethane / 6 h / 20 °C

2.1: oxalyl dichloride / dichloromethane / 1 h / 0 °C

2.2: 2 h

3.1: boron tribromide / dichloromethane

With oxalyl dichloride; tin(II) chloride dihdyrate; boron tribromide; In methanol; dichloromethane;
DOI:10.1021/jm201699w

Reference yield:

: 7217-59-6
2-Methoxybenzenethiol

: 1374007-10-9
N-(4-((2-hydroxyphenyl)sulfonyl)phenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / ethanol / 80 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C

3.1: tin(II) chloride dihdyrate / methanol; dichloromethane / 6 h / 20 °C

4.1: oxalyl dichloride / dichloromethane / 1 h / 0 °C

4.2: 2 h

5.1: boron tribromide / dichloromethane

With oxalyl dichloride; tin(II) chloride dihdyrate; boron tribromide; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm201699w