73015-47-1Relevant academic research and scientific papers
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: Synthesis, structure-activity relationships, and pharmacokinetics
Ndungu, J. Maina,Krumm, Stefanie A.,Yan, Dan,Arrendale, Richard F.,Reddy, G. Prabhakar,Evers, Taylor,Howard, Randy,Natchus, Michael G.,Saindane, Manohar T.,Liotta, Dennis C.,Plemper, Richard K.,Snyder, James P.,Sun, Aiming
, p. 4220 - 4230 (2012/06/30)
The measles virus (MeV), a member of the paramyxovirus family, is an important cause of pediatric morbidity and mortality worldwide. In an effort to provide therapeutic treatments for improved measles management, we previously identified a small, non-nucl
MOLECULAR POLARIZABILITY OF ORGANIC COMPOUNDS AND THEIR COMPLEXES. XLIV. CONFORMATIONS OF DIARYL SULFONES IN DIOXANE
Bulgarevich, S. B.,Movshovich, D. Ya.,Ivanova, N. A.,Filippov, S. E.,Finocchiaro, P.,Failla, S.
, p. 379 - 387 (2007/10/02)
We determined molar Kerr constants and dipole moments in dioxane solutions for a number of diaryl sulfones with various substituents in the aromatic nuclei.The data obtained were analyzed to establish the preferential molecular conformations.It was shown that diaryl sulfones occur in solution mainly in the form of orthogonal or planar-orthogonal conformers, or as an equilibrium between these two.In the orthogonal conformer both aromatic rings are perpendicular to the plane of the CArSCAr bonds, whereas in the planar-orthogonal conformer one ring is coplanar and the other orthogonal to this plane.The orthogonal orientation of aromatic rings relative to the CArSCAr plane originates from the ?-conjugation of the nuclei and the sulfonyl gruop of the sulfone molecules.
Therapeutic amides
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, (2008/06/13)
Amides having formula I: STR1 wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful in the treatment of urinary incontinence. Further provided are processes for preparing the amides and pharmaceutical compositions containing them.
Conformational investigation of diarylsulphones by Kerr effect and dipole moment methods
Bulgarevich, S. B.,Movshovich, D. Ya.,Ivanova, N. A.,Filippov, S. E.,Finocchiario, P.,Failla, S.
, p. 365 - 376 (2007/10/02)
Molar Kerr constants and electric dipole moments are reported for (C6H5)2SO2, (4Cl-C6H4)(C6H5)SO2, (2,4,6-Me3C6H2)(4'-Br-C6H4)SO2, (4-NO2C6H4)2SO2, (4-MeOC6H4)(4'-NO2C6H4)SO2, (2-MeOC6H4)(4'-NO2C6H4)SO2, (2-NO2C6H4)(4'-MeOC6H4)SO2 and (2-MeOC6H4)(2'-NO2C6H4)SO2 as solutes in dioxane solution at 298 K.The data are analysed in terms of the preferred conformations adopted in solution.In most cases these data are consistent with the presence, in dioxane, of orthogonal or planar-orthogonal conformers, or of a mixture of them.In the orthogonal rotamer both aromatic rings are approximately perpendicular to the CAr-S-CAr molecular reference plane whereas in the planar-orthogonal conformer one ring is coplanar and the other is orthogonal to the reference CAr-S-CAr plane.
