methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate

Base Information

Chemical Name:methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate
CAS No.:234124-32-4
Molecular Formula:C₁₆H₂₀N₂O₃
Molecular Weight:288.346
Hs Code.:

Synonyms:methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate

Suppliers and Price of methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate

There total 5 articles about methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {1-[(2-Amino-acetyl)-phenethyl-amino]-cyclopropyl}-chloro-acetic acid methyl ester

: 234124-32-4
methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate

: 6'-chlorohexahydro-4'-(2-phenylethyl)spiro(cyclopropane-1,5'-<1H><1,4>diazepine)-3',7'-dione

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 0 ℃; Yield given; Yields of byproduct given; pH=9-10;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1345::AID-EJOC1345>3.0.CO;2-2

Reference yield:

: 82979-45-1
methyl 2-chloro-2-cyclopropylideneacetate

: 234124-32-4
methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 °C

2: DCC, pyridine / tetrahydrofuran / 0 °C

3: TFA / CH₂Cl₂ / 0 °C

4: aq. NaHCO₃ / CH₂Cl₂ / 0 °C / pH=9-10

With pyridine; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1345::AID-EJOC1345>3.0.CO;2-2

Reference yield:

: 64-04-0
phenethylamine

: 234124-32-4
methyl hexahydro-6'-oxo-1'-(2-phenylethyl)spiro(cyclopropane-1,2'-pyrazine)-3'-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 °C

2: DCC, pyridine / tetrahydrofuran / 0 °C

3: TFA / CH₂Cl₂ / 0 °C

4: aq. NaHCO₃ / CH₂Cl₂ / 0 °C / pH=9-10

With pyridine; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/(SICI)1099-0690(199906)1999:6<1345::AID-EJOC1345>3.0.CO;2-2