4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

Base Information

• Chemical Name: 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine
• CAS No.: 1391715-56-2
• Molecular Formula: C₄₀H₄₆N₆O₆Si
• Molecular Weight: 734.927
• Mol file: 1391715-56-2.mol

Synonyms:4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property of 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

There total 1 articles about 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-{[(dimethylamino)ethylidene]amino}-3-iodo-1-(5'-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine (1185880-43-6) + trimethylsilylacetylene (1066-54-2) → 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine (1391715-56-2)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1039/c2ob25647a

Reference yield: 40.0%

4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine (1391715-56-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine (1391715-58-4)

Guidance literature:

With silver nitrate; triethylamine; In tetrahydrofuran; at 20 ℃; for 19.0833h; Inert atmosphere;

DOI:10.1039/c2ob25647a

Reference yield:

4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine (1391715-56-2) + tert-butyldimethylsilyl chloride (18162-48-6) → 4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tertbutyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine (1391715-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: silver nitrate; triethylamine / tetrahydrofuran / 19.08 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 20 °C / Inert atmosphere

With silver nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c2ob25647a

upstream raw materials:

4-{[(dimethylamino)ethylidene]amino}-3-iodo-1-(5'-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine

trimethylsilylacetylene

Downstream raw materials:

4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine

4-{[(dimethylamino)ethylidene]amino}-3-[(trimethylsilyl)ethynyl]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tertbutyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine