methyl 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylate

Base Information

Chemical Name:methyl 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylate
CAS No.:809273-68-5
Molecular Formula:C₂₀H₂₆F₂N₂O₂
Molecular Weight:364.435
Hs Code.:

Synonyms:methyl 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylate

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Chemical Property of methyl 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylate

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Technology Process of methyl 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylate

There total 6 articles about methyl 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₈F₂N₂O₃

: 809273-68-5
methyl 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylate

Guidance literature:: C₂₀H₂₈F₂N₂O₃; With acetic acid; at 150 ℃; for 3h; Microwave irradiation;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 809273-65-2
(4,4-difluorocyclohexane)methylamine hydrochloride

: 809273-68-5
methyl 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 75 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

3: dmap / dichloromethane / 4 h / 20 °C

4: acetic acid / 3 h / 150 °C / Microwave irradiation

With dmap; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 809273-66-3
methyl {[(4,4-difluorocyclohexyl)methanol]amino}-3-nitrobenzoate

: 809273-68-5
methyl 2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

2: dmap / dichloromethane / 4 h / 20 °C

3: acetic acid / 3 h / 150 °C / Microwave irradiation

With dmap; hydrogen; acetic acid; palladium 10% on activated carbon; In dichloromethane; ethyl acetate;