3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Base Information

Chemical Name:3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester
CAS No.:1257235-78-1
Molecular Formula:C₂₆H₃₀F₂N₂O₅
Molecular Weight:488.531
Hs Code.:

Synonyms:3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Suppliers and Price of 3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

There total 19 articles about 3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 2713-33-9
3,4-difluorophenol

: 1257235-80-5
6-methanesulfonyloxymethyl-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester

: 1257235-78-1
3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 60 ℃;

Reference yield:

: 2713-33-9
3,4-difluorophenol

: 1257235-76-9
3-hydroxymethyl-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

: 1257235-78-1
3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In benzene; at 20 ℃;

Reference yield:

: 757247-71-5
tert-butyl (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-formylpyrrolidine-1-carboxylate

: 1257235-78-1
3-(3,4-difluoro-phenoxymethyl)-hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: triethylamine

2: thionyl chloride; triethylamine / dichloromethane / -78 °C

3: cerium(III) chloride; sodium iodide / methanol; water; acetonitrile / 20 - 40 °C

4: hydrogen / Raney Ni / ethanol; water / 1.5 h / 2585.81 Torr

5: triethylamine / dichloromethane / 0 - 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

7: dmap / dichloromethane / 0 °C

8: sodium hydride / N,N-dimethyl-formamide / 0 °C

9: sodium periodate / ruthenium trichloride / 1-methyl-pyrrolidin-2-one; tetrachloromethane; water; acetonitrile

10: diethyl ether

11: lithium borohydride / tetrahydrofuran / 0 °C

12: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 20 °C

With sodium periodate; lithium borohydride; thionyl chloride; cerium(III) chloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; triphenylphosphine; sodium iodide; dmap; ruthenium trichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;