2-bromo-3-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-4-isopropenyl-cyclohexan-1-ethylene ketal

Base Information

Chemical Name:2-bromo-3-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-4-isopropenyl-cyclohexan-1-ethylene ketal
CAS No.:145104-78-5
Molecular Formula:C₂₄H₃₅BrO₄
Molecular Weight:470.42
Hs Code.:

Synonyms:2-bromo-3-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-4-isopropenyl-cyclohexan-1-ethylene ketal

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Chemical Property of 2-bromo-3-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-4-isopropenyl-cyclohexan-1-ethylene ketal

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Technology Process of 2-bromo-3-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-4-isopropenyl-cyclohexan-1-ethylene ketal

There total 5 articles about 2-bromo-3-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-4-isopropenyl-cyclohexan-1-ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 7381-30-8
2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane

: 145104-77-4
3-bromo-4-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-6,6-dimethylbicyclo<3.1.1>-hept-2-one

: 145104-78-5
2-bromo-3-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-4-isopropenyl-cyclohexan-1-ethylene ketal

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 22 ℃; for 60h;
DOI:10.1016/S0040-4020(01)85608-8

Reference yield:

: 38651-65-9
(1R,5S)-(+)-nopinone

: 145104-78-5
2-bromo-3-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-4-isopropenyl-cyclohexan-1-ethylene ketal

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / N-bromosuccinimide, (PhCO₂)2 / CCl₄ / 48 h / Heating

2: 76 percent / Li₂CO₃, LiBr / dimethylformamide / 6 h / 130 °C

3: 1) n-BuLi, 2) lithium 2-thienylcyanocuprate, 3) BF₃*Et₂O / 1) THF, hexane, a) 0 deg C, 10 min b) 25 deg C, 2,5 h, 2) -78 deg C, 3) THF, -78 deg C, 5-6 h

4: 65 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 60 h / 22 °C

With N-Bromosuccinimide; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; lithium carbonate; thien-2-yl(cyano)copper lithium; lithium bromide; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85608-8

Reference yield:

: 58738-65-1
1,3-dimethoxy-5-[5'-(2H₃)-pentyl]benzene

: 145104-78-5
2-bromo-3-<(2,6-dimethoxy-4-(5'-(2)H3)pentyl)phenyl>-4-isopropenyl-cyclohexan-1-ethylene ketal

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi, 2) lithium 2-thienylcyanocuprate, 3) BF₃*Et₂O / 1) THF, hexane, a) 0 deg C, 10 min b) 25 deg C, 2,5 h, 2) -78 deg C, 3) THF, -78 deg C, 5-6 h

2: 65 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 60 h / 22 °C

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; thien-2-yl(cyano)copper lithium; In dichloromethane;
DOI:10.1016/S0040-4020(01)85608-8