5'-O-(4-monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-dehydro-3'-(E)-(N-methyloximino)-5-methyluridine

Base Information

Chemical Name:5'-O-(4-monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-dehydro-3'-(E)-(N-methyloximino)-5-methyluridine
CAS No.:153842-96-7
Molecular Formula:C₃₇H₄₅N₃O₇Si
Molecular Weight:671.866
Hs Code.:

Synonyms:5'-O-(4-monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-dehydro-3'-(E)-(N-methyloximino)-5-methyluridine

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Chemical Property of 5'-O-(4-monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-dehydro-3'-(E)-(N-methyloximino)-5-methyluridine

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Technology Process of 5'-O-(4-monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-dehydro-3'-(E)-(N-methyloximino)-5-methyluridine

There total 5 articles about 5'-O-(4-monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-dehydro-3'-(E)-(N-methyloximino)-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 153842-94-5
1-<5-O-(4-monomethoxytrityl)-2-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuran-3-ulosyl>thymine

: 153842-96-7
5'-O-(4-monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-dehydro-3'-(E)-(N-methyloximino)-5-methyluridine

Guidance literature:: In pyridine; at 5 ℃; for 48h; Yield given;
DOI:10.1016/S0040-4020(01)80209-X

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 153842-96-7
5'-O-(4-monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-dehydro-3'-(E)-(N-methyloximino)-5-methyluridine

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / imidazole / dimethylformamide / Ambient temperature

2: CrO₃/pyridine/Ac₂O / CH₂Cl₂ / Ambient temperature

3: pyridine / 48 h / 0 - 5 °C

With pyridine; 1H-imidazole; chromium(VI) oxide; acetic anhydride; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)85027-4

Reference yield:

: 156386-28-6
1-(5'-O-MMTr-2'-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl)thymine

: 153842-96-7
5'-O-(4-monomethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-3'-deoxy-3'-dehydro-3'-(E)-(N-methyloximino)-5-methyluridine

Guidance literature:: Multi-step reaction with 2 steps

1: CrO₃/pyridine/Ac₂O / CH₂Cl₂ / Ambient temperature

2: pyridine / 48 h / 0 - 5 °C

With pyridine; chromium(VI) oxide; acetic anhydride; In pyridine; dichloromethane;
DOI:10.1016/S0040-4020(01)85027-4