3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid

Base Information

Chemical Name:3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid
CAS No.:160730-14-3
Molecular Formula:C₁₆H₁₇NO₆S
Molecular Weight:351.38
Hs Code.:

Synonyms:3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid

Suppliers and Price of 3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid

There total 1 articles about 3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 19169-25-6
7-(toluene-4-sulfonyl)-7-aza-bicyclo[2.2.1]hept-2-ene-2,3-dicarboxylic acid dimethyl ester

: 160730-14-3
3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In 1,2-dimethoxyethane; at 20 ℃; for 1h;
DOI:10.1248/cpb.42.1432

Reference yield: 75.0%

: 160730-14-3
3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 160730-15-4
methyl 3-(tert-butyloxycarbonyl)amino-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylate

Guidance literature:: With diphenyl-phosphinic acid; triethylamine; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 13.5h;
DOI:10.1248/cpb.42.1432

Reference yield:

: 160730-14-3
3-methoxycarbonyl-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>hept-2-ene-2-carboxylic acid

: endo-2-(2-dimethylamino-5-pyridyl)-7-(p-toluenesulfonyl)-7-azabicyclo<2.2.1>heptane

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / DPPA, Et₃N / dimethylformamide / 13.5 h / 80 - 85 °C

2: 68 percent / 5percent aq. HCl / dioxane / 14.5 h / 80 °C

3: 1.) BuLi / 1.) hexane, Et₂O, -80 deg C, 10 min, 2.) hexane, Et₂O, THF, from -76 deg C to -74 deg C, 20 min

4: 68 percent / Burgess Reagent / benzene / 3 h / 87 - 90 °C

5: 72 percent / H₂, 10percent aq. HCl / 10percent Pd/C / propan-2-ol / 4 h / 19 °C

6: 6 percent / POCl₃, DMF / 1.) 0 deg C, 1 h, 2.) from 95 deg C to 99 deg C, 3.5 h

With hydrogenchloride; n-butyllithium; Burgess Reagent; diphenyl-phosphinic acid; hydrogen; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; palladium on activated charcoal; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol; benzene;
DOI:10.1248/cpb.42.1432