1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane

Base Information

Chemical Name:1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane
CAS No.:146964-16-1
Molecular Formula:C₂₁H₃₁O₂PSi
Molecular Weight:374.535
Hs Code.:

Synonyms:1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane

Suppliers and Price of 1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane

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Technology Process of 1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane

There total 4 articles about 1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 889-57-6
3-(diphenylphosphinoyl)-1-propanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 146964-16-1
1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

Reference yield: 68.0%

: C₂₁H₃₁OPSi

: 146964-16-1
1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane

Guidance literature:: With dihydrogen peroxide; In methanol; at 20 ℃; for 1h; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.tetlet.2020.152125

Reference yield:

: 829-85-6
diphenylphosphane

: 146964-16-1
1-tert-Butyldimethylsilyloxy-3-diphenylphosphinoylpropane

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran

2: bis(benzonitrile)palladium(II) dichloride; caesium carbonate / toluene / 36 h / 80 °C / Schlenk technique; Inert atmosphere

3: dihydrogen peroxide / methanol / 1 h / 20 °C / Schlenk technique; Inert atmosphere

With bis(benzonitrile)palladium(II) dichloride; dihydrogen peroxide; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.tetlet.2020.152125