(1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione

Base Information

Chemical Name:(1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione
CAS No.:247171-11-5
Molecular Formula:C₂₁H₃₁NO₃Si
Molecular Weight:373.568
Hs Code.:

Synonyms:(1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione

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Chemical Property of (1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione

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Technology Process of (1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione

There total 3 articles about (1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 199103-41-8
(1S,6R,9S)-7-benzyl-9-hydroxy-7-azabicyclo[4.2.1]nonane-4,8-dione

: 247171-11-5
(1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1002/(SICI)1521-3773(19990802)38:15<2214::AID-ANIE2214>3.0.CO;2-V

Reference yield:

: 199103-44-1
1-benzyl-5-ethoxy-4-hydroxy-3-(buta-2,3-dienyl)-2-pyrrolidinone

: 247171-11-5
(1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / NaI / 18 h / 85 °C

2: NH₃ / methanol / 0.25 h / 20 °C

3: 96 percent / imidazole; DMAP / CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; dmap; ammonia; sodium iodide; In methanol; dichloromethane; 1: Cyclization / 2: Substitution / 3: Etherification;
DOI:10.1002/(SICI)1521-3773(19990802)38:15<2214::AID-ANIE2214>3.0.CO;2-V

Reference yield:

: 247171-10-4
Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester

: 247171-11-5
(1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ / methanol / 0.25 h / 20 °C

2: 96 percent / imidazole; DMAP / CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; dmap; ammonia; In methanol; dichloromethane; 1: Substitution / 2: Etherification;
DOI:10.1002/(SICI)1521-3773(19990802)38:15<2214::AID-ANIE2214>3.0.CO;2-V