Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester

Base Information

Chemical Name:Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester
CAS No.:247171-10-4
Molecular Formula:C₁₆H₁₇NO₄
Molecular Weight:287.315
Hs Code.:

Synonyms:Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester

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Technology Process of Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester

There total 1 articles about Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 64-18-6
formic acid

: 199103-44-1
1-benzyl-5-ethoxy-4-hydroxy-3-(buta-2,3-dienyl)-2-pyrrolidinone

: 247171-10-4
Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester

: 247171-09-1
(1S,6R,9S)-formic acid 7-benzyl-4-iodo-8-oxo-7-azabicyclo[4.2.1]non-3-en-9-yl ester

Guidance literature:: With sodium iodide; at 85 ℃; for 18h;
DOI:10.1002/(SICI)1521-3773(19990802)38:15<2214::AID-ANIE2214>3.0.CO;2-V

Reference yield:

: 247171-10-4
Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester

: 199103-41-8
(1S,6R,9S)-7-benzyl-9-hydroxy-7-azabicyclo[4.2.1]nonane-4,8-dione

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 0.25h;
DOI:10.1002/(SICI)1521-3773(19990802)38:15<2214::AID-ANIE2214>3.0.CO;2-V

Reference yield:

: 247171-10-4
Formic acid (1S,6R,9S)-7-benzyl-4,8-dioxo-7-aza-bicyclo[4.2.1]non-9-yl ester

: 247171-11-5
(1S,6R,9S)-7-benzyl-9-(tert-butyldimethylsilyloxy)-7-azabicyclo[4.2.1]nonan-4,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ / methanol / 0.25 h / 20 °C

2: 96 percent / imidazole; DMAP / CH₂Cl₂ / 18 h / 20 °C

With 1H-imidazole; dmap; ammonia; In methanol; dichloromethane; 1: Substitution / 2: Etherification;
DOI:10.1002/(SICI)1521-3773(19990802)38:15<2214::AID-ANIE2214>3.0.CO;2-V