dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Base Information

Chemical Name:dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate
CAS No.:932393-86-7
Molecular Formula:C₁₈H₂₂N₂O₅
Molecular Weight:346.383
Hs Code.:

Synonyms:dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

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Chemical Property of dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

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Technology Process of dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

There total 4 articles about dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 89-25-8
edaravone

: 932393-86-7
dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: edaravone; With sodium amide; In N,N-dimethyl-formamide; at 10 - 15 ℃;

acrylic acid methyl ester; In N,N-dimethyl-formamide; for 7h; Further stages.;
DOI:10.1002/jhet.5570440108

Reference yield: 33.0%

: 138853-66-4
(3-methyl-1-phenyl-1H-pyrazol-5-yl) acetate

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 932393-86-7
dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

: 1415230-86-2
methyl 3-(5-acetoxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)propanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2012.09.096

Reference yield:

: 89-25-8
edaravone

: 932393-86-7
dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

: 1415230-86-2
methyl 3-(5-acetoxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 12 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; 2: |Michael Addition;
DOI:10.1016/j.tetlet.2012.09.096