138853-66-4

Upstream product

• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 71-43-2 benzene 
• 89-25-8 edaravone 

Downstream Products

• 19374-75-5 3-methyl-1-phenylpyrazole-4,5-dione 4-phenylhydrazone 
• 1131-17-5 5-chloro-3-methyl-1-phenyl-1H-pyrazole 
• 1415230-70-4 3-methyl-4-(3-oxobutyl)-1-phenyl-1H-pyrazol-5-yl acetate 
• 1415230-94-2 4,4'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)bis(butan-2-one) 
• 1415230-85-1 3-methyl-4-(3-oxopentyl)-1-phenyl-1H-pyrazol-5-yl acetate 
• 1415231-02-5 1,1'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)bis(pentan-3-one) 
• 932393-86-7 dimethyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate 
• 1415230-86-2 methyl 3-(5-acetoxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)propanoate 
• 1415230-87-3 phenyl 3-(5-acetoxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)propanoate 
• 1415231-03-6 diphenyl 3,3'-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate 

Relevant academic research and scientific papers

Synthesis of 1-acyl-1,2-dihydro-3H-pyrazol-3-ones via Lewis acid-mediated rearransement of 3-acyloxypyrazoles

The unusual formation of 1-acyl-1,2-dihydro-3H-pyrazol-3-ones starting from 3-acyloxypyrazoles by Fries-type rearrangement is described. Under normal conditions, acylation of 2,4-dihydro-3H-pyrazol-3-ones 1 and 2 with acid chlorides or anhydrides in the p

Antioxidant and acetylcholinesterase inhibition activity of aliphatic and aromatic edaravone derivatives

As Alzheimer disease (AD) is a multifactorial condition, it should be tackled with drugs targeting multiple key pathways. A series of aliphatic (2–8) and aromatic (9–15) edaravone derivatives were synthesized, characterized, and evaluated as antioxidant a

A facile organocatalyzed Michael addition of pyrazolines to α,β-unsaturated carbonyl compounds

A new highly efficient cascade reaction of pyrazolines with α,β-unsaturated carbonyl compounds catalyzed by DBU was reported. The process underwent the first deprotection/Michael addition reaction to give 4-substituted pyrazoline derivatives, which were further converted into 4,4-di-substituted pyrazolone derivatives through the second deprotection/Michael reaction. The mechanism for this reaction was also studied.

A novel one-pot synthesis of substituted 5-benzoyl- and 5-acetylamino-1H,6H-pyranopyrazolones

A convenient one-pot synthesis of some 5-benzoyl- and 5-acetylamino-1H,6H-pyranopyrazolones (4) by the reaction of 2-pyrazolin-5-ones (1) with hippuric/aceturic acid and triethyl orthoformate in the presence of acetic anhydride, in good yield (75-8