methyl (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylate

Base Information

• Chemical Name: methyl (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylate
• CAS No.: 169908-34-3
• Molecular Formula: C₁₈H₁₇NO₃S
• Molecular Weight: 327.404
• Mol file: 169908-34-3.mol

Synonyms:methyl (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylate

Chemical Property of methyl (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of methyl (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylate

There total 1 articles about methyl (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl (4R)-2-phenylthiazolidine-4-carboxylate (198991-76-3,69739-20-4) + benzoyl chloride (98-88-4) → methyl (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylate (169908-34-3)

Guidance literature:

methyl (4R)-2-phenylthiazolidine-4-carboxylate; With triethylamine; In tetrahydrofuran; at -10 - 20 ℃; for 0.25h;

benzoyl chloride; In tetrahydrofuran; at -10 - 20 ℃; for 1h;

DOI:10.1016/S0040-4020(02)00463-5

Reference yield: 74.0%

methyl (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylate (169908-34-3) → (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylic acid (125813-73-2)

Guidance literature:

With lithium iodide; In ethyl acetate; for 6h; Heating;

DOI:10.1016/S0040-4020(02)00463-5

Reference yield:

methyl (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylate (169908-34-3) → (3R)-7-acetyl-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / LiI / ethyl acetate / 6 h / Heating

2: 37 percent / acetic anhydride / 15 h / Heating

With acetic anhydride; lithium iodide; In ethyl acetate;

DOI:10.1016/S0040-4020(02)00463-5

upstream raw materials:

methyl (4R)-2-phenylthiazolidine-4-carboxylate

benzoyl chloride

Downstream raw materials:

(2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylic acid

dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate