dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

Base Information

• Chemical Name: dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate
• CAS No.: 473910-47-3
• Molecular Formula: C₂₂H₁₉NO₄S
• Molecular Weight: 393.463
• Mol file: 473910-47-3.mol

Synonyms:dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

Chemical Property of dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

There total 5 articles about dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dimethyl acetylenedicarboxylate (762-42-5) + (2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylic acid (125813-73-2) → dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate (473910-47-3)

Guidance literature:

With acetic anhydride; for 4h; Heating;

DOI:10.1016/S0040-4020(02)00463-5

Reference yield:

(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid (196930-46-8) → dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate (473910-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / -10 - 20 °C

1.2: 76 percent / tetrahydrofuran / 1 h / -10 - 20 °C

2.1: 90 percent / acetic anhydride / 4 h / Heating

With acetic anhydride; triethylamine; In tetrahydrofuran;

DOI:10.1016/S0040-4020(02)00463-5

Reference yield:

benzoyl chloride (98-88-4) → dimethyl (3R)-3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate (473910-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / -10 - 20 °C

1.2: 76 percent / tetrahydrofuran / 1 h / -10 - 20 °C

2.1: 90 percent / acetic anhydride / 4 h / Heating

With acetic anhydride; triethylamine; In tetrahydrofuran;

DOI:10.1016/S0040-4020(02)00463-5

upstream raw materials:

dimethyl acetylenedicarboxylate

(2R,4R)-N-benzoyl-2-phenylthiazolidine-4-carboxylic acid

(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid

benzoyl chloride

Downstream raw materials:

C₂₀H₁₉NO₂S

dimethyl 2-phenyl-5-styryl-1H-pyrrole-3,4-dicarboxylate

dimethyl 3,5-diphenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate-2,2-dioxide