3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid

Base Information

Chemical Name:3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid
CAS No.:871656-56-3
Molecular Formula:C₂₀H₂₀FNO₆
Molecular Weight:389.38
Hs Code.:

Synonyms:3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid

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Chemical Property of 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid

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Technology Process of 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid

There total 10 articles about 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871656-57-4
methyl 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoate

: 871656-56-3
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 863505-11-7
azetidin-1-yl-(3,4-difluoro-phenyl)-methanone

: 871656-74-5
methyl 3-hydroxy-5-[(1S)-2-hydroxy-1-methylethyloxy]benzoate

: 871656-56-3
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid

Guidance literature:: azetidin-1-yl-(3,4-difluoro-phenyl)-methanone; methyl 3-hydroxy-5-[(1S)-2-hydroxy-1-methylethyloxy]benzoate; With caesium carbonate; In ISOPROPYLAMIDE; at 120 ℃; for 22h;

With lithium hydroxide; water; In ISOPROPYLAMIDE; for 24h;

Reference yield:

: 455-86-7
3,4-Difluorobenzoic acid

: 871656-56-3
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: caesium carbonate / ISOPROPYLAMIDE / 22 h / 120 °C

3.2: 24 h

With oxalyl dichloride; caesium carbonate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; ISOPROPYLAMIDE;