3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-([tert-butyl(dimethyl)silyl]oxy)-1-methylethoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide

Base Information

Chemical Name:3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-([tert-butyl(dimethyl)silyl]oxy)-1-methylethoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide
CAS No.:871657-62-4
Molecular Formula:C₂₉H₃₇FN₄O₅SSi
Molecular Weight:600.786
Hs Code.:

Synonyms:3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-([tert-butyl(dimethyl)silyl]oxy)-1-methylethoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide

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Chemical Property of 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-([tert-butyl(dimethyl)silyl]oxy)-1-methylethoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide

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Technology Process of 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-([tert-butyl(dimethyl)silyl]oxy)-1-methylethoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide

There total 12 articles about 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-([tert-butyl(dimethyl)silyl]oxy)-1-methylethoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17467-35-5
3-methyl-1,2,4-thiadiazol-5-amine

: 871656-73-4
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid

: 871657-62-4
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-([tert-butyl(dimethyl)silyl]oxy)-1-methylethoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h;

Reference yield:

: 54915-31-0
methyl 3-(benzyloxy)-5-hydroxybenzoate

: 871657-62-4
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-([tert-butyl(dimethyl)silyl]oxy)-1-methylethoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: PS-triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 20 h / 20 °C

3.1: trimethylsilyl iodide / acetonitrile / 24 h

3.2: 0.17 h

4.1: caesium carbonate / ISOPROPYLAMIDE / 22 h / 120 °C

4.2: 24 h

5.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 24 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 16 h / 20 °C

With 1H-imidazole; PS-triphenylphosphine; trimethylsilyl iodide; di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; ISOPROPYLAMIDE; acetonitrile;

Reference yield:

: 455-86-7
3,4-Difluorobenzoic acid

: 871657-62-4
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-([tert-butyl(dimethyl)silyl]oxy)-1-methylethoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: caesium carbonate / ISOPROPYLAMIDE / 22 h / 120 °C

3.2: 24 h

4.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 24 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 16 h / 20 °C

With 1H-imidazole; oxalyl dichloride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; N,N-dimethyl-formamide; In DMF (N,N-dimethyl-formamide); dichloromethane; ISOPROPYLAMIDE;