3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid

Base Information

Chemical Name:3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid
CAS No.:871656-73-4
Molecular Formula:C₂₆H₃₄FNO₆Si
Molecular Weight:503.643
Hs Code.:

Synonyms:3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid

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Chemical Property of 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid

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Technology Process of 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid

There total 10 articles about 3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871656-56-3
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]benzoic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 871656-73-4
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid

Guidance literature:: With 1H-imidazole; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 24h;

Reference yield:

: 455-86-7
3,4-Difluorobenzoic acid

: 871656-73-4
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: caesium carbonate / ISOPROPYLAMIDE / 22 h / 120 °C

3.2: 24 h

4.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 24 h / 20 °C

With 1H-imidazole; oxalyl dichloride; caesium carbonate; triethylamine; N,N-dimethyl-formamide; In DMF (N,N-dimethyl-formamide); dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 851885-42-2
methyl 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoate

: 871656-73-4
3-[4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 20 h / 20 °C

2.1: trimethylsilyl iodide / acetonitrile / 24 h

2.2: 0.17 h

3.1: caesium carbonate / ISOPROPYLAMIDE / 22 h / 120 °C

3.2: 24 h

4.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 24 h / 20 °C

With 1H-imidazole; trimethylsilyl iodide; hydrogen; caesium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; ISOPROPYLAMIDE; acetonitrile;